Cytogenetics of pediatric acute myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Pediatric Acute Myeloid Leukemia
Acute leukemias are clonal diseases characterized by a maturation arrest and by enhanced proliferation of hematopoietic precursor cells, which normally would differentiate into mature blood cells. The leukemic cells are released from the bone marrow into the peripheral blood and may accumulate in vital organs such as the spleen, liver, skin, central nervous system and lymph nodes. Chronic leuke...
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Prognostic factors in acute myeloid leukemia (AML) may be subdivided into those related to patient characteristics and general health condition, and those related to characteristics of the tumor.[1] Among the AML-related factors, the karyotype of the leukemic cells is the strongest independent prognostic indicator for response to therapy and for survival, and allows one to stratify patients int...
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Background: Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in NPM, FLT3, CEBPA, and BAALC genes are observed. Initially, high BAALC (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AM...
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Background:Brain and Acute Leukemia Cytoplasmic (BAALC) is a gene which its expression is confined to progenitor cells; therefore, no expression has been illustrated in mature cells of bone marrow or white blood cells (WBC). In addition, high BAALC expression is associated with poor prognosis in Acute Myeloid Leukemia (AML) individuals and is considered as an important risk factor in Cyto...
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Acute myeloid leukemia (AML) as a distortion of blood cells involves the differentiation of hematopoietic stem cells. Several studies established the irregular overexpression of specific genes is a common finding in patients with AML. The ectopic viral integration site-1 (EVI1) gene is a proto-oncogene subject to alternative splicing, and encodes a zinc-finger protein that acts as a tr...
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ژورنال
عنوان ژورنال: European Journal of Haematology
سال: 2009
ISSN: 0902-4441,1600-0609
DOI: 10.1111/j.1600-0609.2009.01308.x